GYPA

GENERAL INFORMATION

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Gene name

GYPA

Gene description

Glycophorin A (MNS blood group)

Protein class

Blood group antigen proteins
CD markers
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (bone marrow)
GTEx:Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein localization

Selective expression in erythrocytes.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Data reliability

Supportive based on 2 antibodies.
HPA014811 , CAB002658
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (bone marrow)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (spleen)

Organ

Expression



GENE INFORMATION

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Gene name

GYPA (HGNC Symbol)

Synonyms

CD235a, GPA, MN, MNS

Description

Glycophorin A (MNS blood group) (HGNC Symbol)

Entrez gene summary

Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q31.21

Chromosome location (bp)

144109303 - 144140751

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170180 (version 78.38)

Entrez gene

2993

UniProt

P02724 (UniProt - Evidence at protein level)

neXtProt

NX_P02724

Antibodypedia

GYPA antibodies


PROTEIN BROWSER

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ENST00000324022
 
ENST00000360771
 
ENST00000503627
 
ENST00000504786
 
ENST00000512064
 
ENST00000512789
 
ENST00000535709
 
ENST00000616983
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GYPA-001 ENSP00000354003
ENST00000360771
P02724
Show all »
Show » Show » 150 16.4 Yes 1
GYPA-002 ENSP00000324483
ENST00000324022
P02724
Show all »
Show » Show » 117 13 No 1
GYPA-004 ENSP00000425193
ENST00000512789
Q13030
Show all »
Show » Show » 85 9.3 Yes 1
GYPA-005 ENSP00000425549
ENST00000504786
E7EQF3
Show all »
Show » Show » 118 12.8 Yes 1
GYPA-006 ENSP00000421243
ENST00000503627
E9PH25
Show all »
Show » Show » 105 11.3 Yes 1
GYPA-007 ENSP00000426130
ENST00000512064
E9PD10
Show all »
Show » Show » 137 14.9 Yes 1
GYPA-201 ENSP00000445398
ENST00000535709
Q14438
Show all »
Show » Show » 148 16.2 No 1
GYPA-202 ENSP00000478329
ENST00000616983
Q14438
Show all »
Show » Show » 148 16.2 No 1