ADRA1B

GENE INFORMATION

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Gene name

ADRA1B

Synonyms

Description

adrenoceptor alpha 1B (HGNC Symbol)

Entrez gene summary

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]

Chromosome

5 (Chromosome progress)

Cytoband

q33.3

Chromosome location (bp)

159343790 - 159399551

Ensembl

ENSG00000170214 (version 73.37)

Entrez gene

147

UniProt

P35368 (UniProt - Evidence at protein level)

neXtProt

NX_P35368

Antibodypedia

ADRA1B antibodies
 

PROTEIN VIEW

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ADRA1B-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADRA1B-001 ENSP00000306662
ENST00000306675
P35368
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