GENERAL INFORMATIONi
Gene namei CDK1
Synonyms CDC2, CDC28A
Gene descriptioni Cyclin dependent kinase 1
Protein classi Cancer-related genes
Enzymes
Plasma proteins
Transporters
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 10
Cytoband q21.2
Chromosome location (bp) 60778331 - 60794852
Number of transcriptsi 6
Ensembl ENSG00000170312 (version 103.38)
Entrez gene 983
HGNC HGNC:1722
UniProt P06493 (UniProt - Evidence at protein level)
neXtProt NX_P06493
Antibodypedia CDK1 antibodies


PROTEIN STRUCTUREi

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 61

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

Off
On


PROTEIN BROWSERi
CDK1-201
CDK1-202
CDK1-203
CDK1-204
CDK1-207
CDK1-209


PROTEIN INFORMATIONi
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
CDK1-201
ENSP00000325970
ENST00000316629
P06493 [Direct mapping]
Cyclin-dependent kinase 1
A0A024QZJ8 [Target identity:100%; Query identity:100%]
Cell division cycle 2, G1 to S and G2 to M, isoform CRA_c
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Transporters
   Transporter channels and pores
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000187 [activation of MAPK activity]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000307 [cyclin-dependent protein kinase holoenzyme complex]
GO:0000781 [chromosome, telomeric region]
GO:0001618 [virus receptor activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005876 [spindle microtubule]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007049 [cell cycle]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007098 [centrosome cycle]
GO:0007344 [pronuclear fusion]
GO:0008353 [RNA polymerase II CTD heptapeptide repeat kinase activity]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0014038 [regulation of Schwann cell differentiation]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0016572 [histone phosphorylation]
GO:0016579 [protein deubiquitination]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030332 [cyclin binding]
GO:0030496 [midbody]
GO:0030855 [epithelial cell differentiation]
GO:0031145 [anaphase-promoting complex-dependent catabolic process]
GO:0034501 [protein localization to kinetochore]
GO:0035173 [histone kinase activity]
GO:0042752 [regulation of circadian rhythm]
GO:0043066 [negative regulation of apoptotic process]
GO:0045995 [regulation of embryonic development]
GO:0046718 [viral entry into host cell]
GO:0048511 [rhythmic process]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0072686 [mitotic spindle]
GO:0090166 [Golgi disassembly]
GO:0097125 [cyclin B1-CDK1 complex]
GO:0097472 [cyclin-dependent protein kinase activity]
GO:0097711 [ciliary basal body-plasma membrane docking]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901990 [regulation of mitotic cell cycle phase transition]
GO:1905448 [positive regulation of mitochondrial ATP synthesis coupled electron transport]
Show all
 240 aa
27.5 kDa 		No 0
CDK1-202
ENSP00000362915
ENST00000373809
P06493 [Direct mapping]
Cyclin-dependent kinase 1
A0A024QZJ8 [Target identity:100%; Query identity:100%]
Cell division cycle 2, G1 to S and G2 to M, isoform CRA_c
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Transporters
   Transporter channels and pores
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000187 [activation of MAPK activity]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000307 [cyclin-dependent protein kinase holoenzyme complex]
GO:0000781 [chromosome, telomeric region]
GO:0001618 [virus receptor activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005876 [spindle microtubule]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007049 [cell cycle]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007098 [centrosome cycle]
GO:0007344 [pronuclear fusion]
GO:0008353 [RNA polymerase II CTD heptapeptide repeat kinase activity]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0014038 [regulation of Schwann cell differentiation]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0016572 [histone phosphorylation]
GO:0016579 [protein deubiquitination]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030332 [cyclin binding]
GO:0030496 [midbody]
GO:0030855 [epithelial cell differentiation]
GO:0031145 [anaphase-promoting complex-dependent catabolic process]
GO:0034501 [protein localization to kinetochore]
GO:0035173 [histone kinase activity]
GO:0042752 [regulation of circadian rhythm]
GO:0043066 [negative regulation of apoptotic process]
GO:0045995 [regulation of embryonic development]
GO:0046718 [viral entry into host cell]
GO:0048511 [rhythmic process]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0072686 [mitotic spindle]
GO:0090166 [Golgi disassembly]
GO:0097125 [cyclin B1-CDK1 complex]
GO:0097472 [cyclin-dependent protein kinase activity]
GO:0097711 [ciliary basal body-plasma membrane docking]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901990 [regulation of mitotic cell cycle phase transition]
GO:1905448 [positive regulation of mitochondrial ATP synthesis coupled electron transport]
Show all
 240 aa
27.5 kDa 		No 0
CDK1-203
ENSP00000378699
ENST00000395284
P06493 [Direct mapping]
Cyclin-dependent kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Transporters
   Transporter channels and pores
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000187 [activation of MAPK activity]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000307 [cyclin-dependent protein kinase holoenzyme complex]
GO:0000781 [chromosome, telomeric region]
GO:0001618 [virus receptor activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005876 [spindle microtubule]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007049 [cell cycle]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007098 [centrosome cycle]
GO:0007344 [pronuclear fusion]
GO:0008353 [RNA polymerase II CTD heptapeptide repeat kinase activity]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0014038 [regulation of Schwann cell differentiation]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0016572 [histone phosphorylation]
GO:0016579 [protein deubiquitination]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030332 [cyclin binding]
GO:0030496 [midbody]
GO:0030855 [epithelial cell differentiation]
GO:0031145 [anaphase-promoting complex-dependent catabolic process]
GO:0034501 [protein localization to kinetochore]
GO:0035173 [histone kinase activity]
GO:0042752 [regulation of circadian rhythm]
GO:0043066 [negative regulation of apoptotic process]
GO:0045995 [regulation of embryonic development]
GO:0046718 [viral entry into host cell]
GO:0048511 [rhythmic process]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0072686 [mitotic spindle]
GO:0090166 [Golgi disassembly]
GO:0097125 [cyclin B1-CDK1 complex]
GO:0097472 [cyclin-dependent protein kinase activity]
GO:0097711 [ciliary basal body-plasma membrane docking]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901990 [regulation of mitotic cell cycle phase transition]
GO:1905448 [positive regulation of mitochondrial ATP synthesis coupled electron transport]
Show all
 297 aa
34.1 kDa 		No 0
CDK1-204
ENSP00000397973
ENST00000448257
A0A024QZP7 [Direct mapping]
Cell division cycle 2, G1 to S and G2 to M, isoform CRA_a; Cyclin-dependent kinase 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000278 [mitotic cell cycle]
GO:0003682 [chromatin binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007569 [cell aging]
GO:0008283 [cell population proliferation]
GO:0009636 [response to toxic substance]
GO:0010243 [response to organonitrogen compound]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0014070 [response to organic cyclic compound]
GO:0014075 [response to amine]
GO:0014823 [response to activity]
GO:0016301 [kinase activity]
GO:0016572 [histone phosphorylation]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030261 [chromosome condensation]
GO:0030332 [cyclin binding]
GO:0030544 [Hsp70 protein binding]
GO:0031100 [animal organ regeneration]
GO:0035173 [histone kinase activity]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0044772 [mitotic cell cycle phase transition]
GO:0045471 [response to ethanol]
GO:0045740 [positive regulation of DNA replication]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046686 [response to cadmium ion]
GO:0046688 [response to copper ion]
GO:0048678 [response to axon injury]
GO:0051301 [cell division]
GO:0055015 [ventricular cardiac muscle cell development]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0065003 [protein-containing complex assembly]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0090166 [Golgi disassembly]
Show all
 297 aa
34.1 kDa 		No 0
CDK1-207
ENSP00000430665
ENST00000519078
E5RIU6 [Direct mapping]
Cyclin-dependent kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 189 aa
21.7 kDa 		No 0
CDK1-209
ENSP00000482996
ENST00000614696
A0A087WZZ9 [Direct mapping]
Cyclin-dependent kinase 1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 224 aa
25.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.