CDK1

GENE INFORMATION

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Gene name

CDK1 (HGNC Symbol)

Synonyms

CDC2, CDC28A

Description

cyclin-dependent kinase 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

10 (Chromosome progress)

Cytoband

q21.2

Chromosome location (bp)

62538089 - 62554610

Ensembl

ENSG00000170312 (version 73.37)

Entrez gene

983

UniProt

P06493 (UniProt - Evidence at protein level)

neXtProt

NX_P06493

Antibodypedia

CDK1 antibodies
 

PROTEIN VIEW

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CDK1-007
 
CDK1-008
 
CDK1-009
 
CDK1-013
 
CDK1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK1-007 ENSP00000378699
ENST00000395284
P06493
Show all »
Show » Show » 297 34.1 No 0
CDK1-008 ENSP00000362915
ENST00000373809
P06493
Show all »
Show » Show » 240 27.5 No 0
CDK1-009 ENSP00000397973
ENST00000448257
P06493
Show all »
Show » Show » 297 34.1 No 0
CDK1-013 ENSP00000430665
ENST00000519078
E5RIU6
Show all »
Show » 189 21.7 No 0
CDK1-201 ENSP00000325970
ENST00000316629
P06493
Show all »
Show » Show » 240 27.5 No 0