UBB

GENERAL INFORMATION

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Gene name

UBB

Gene description

Ubiquitin B

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Mainly nuclear expression in all tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation. Caution, targets protein from more than one gene.

Data reliability

Supportive based on 3 antibodies.
HPA041344 , HPA049132 , CAB013048
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

UBB (HGNC Symbol)

Synonyms

FLJ25987, MGC8385

Description

Ubiquitin B (HGNC Symbol)

Entrez gene summary

This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

17

Cytoband

p11.2

Chromosome location (bp)

16380798 - 16382745

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170315 (version 78.38)

Entrez gene

7314

UniProt

P0CG47 (UniProt - Evidence at protein level)

neXtProt

NX_P0CG47

Antibodypedia

UBB antibodies


PROTEIN BROWSER

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ENST00000302182
 
ENST00000395837
 
ENST00000395839
 
ENST00000535788
 
ENST00000577640
 
ENST00000577958
 
ENST00000578706
 
ENST00000614404
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UBB-001 ENSP00000304697
ENST00000302182
P0CG47
Show all »
Show » Show » 229 25.8 No 0
UBB-002 ENSP00000379178
ENST00000395837
P0CG47
Show all »
Show » Show » 229 25.8 No 0
UBB-003 ENSP00000379180
ENST00000395839
P0CG47
Show all »
Show » Show » 229 25.8 No 0
UBB-005 ENSP00000437475
ENST00000535788
B4DV12
Show all »
Show » Show » 153 17.2 No 0
UBB-006 ENSP00000464594
ENST00000577958
J3QSA3
Show all »
Show » Show » 43 4.9 No 0
UBB-007 ENSP00000464510
ENST00000578706
J3QS39
Show all »
Show » Show » 93 10.5 No 0
UBB-008 ENSP00000463156
ENST00000577640
J3QKN0
Show all »
Show » Show » 206 23.2 No 0
UBB-201 ENSP00000478771
ENST00000614404
P0CG47
Show all »
Show » Show » 229 25.8 No 0