DCLK2

GENE INFORMATION

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Gene name

DCLK2 (HGNC Symbol)

Synonyms

DCAMKL2, DCDC3, DCDC3B, DCK2, MGC45428

Description

doublecortin-like kinase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]

Chromosome

4 (Chromosome progress)

Cytoband

q31.23

Chromosome location (bp)

150999426 - 151178609

Ensembl

ENSG00000170390 (version 73.37)

Entrez gene

166614

UniProt

Q8N568 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8N568

Antibodypedia

DCLK2 antibodies
 

PROTEIN VIEW

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DCLK2-001
 
DCLK2-002
 
DCLK2-003
 
DCLK2-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DCLK2-001 ENSP00000296550
ENST00000296550
Q8N568
Show all »
Show » Show » 766 83.6 No 0
DCLK2-002 ENSP00000401916
ENST00000411937
G5E9L9
Show all »
Show » Show » 695 76.1 No 0
DCLK2-003 ENSP00000303887
ENST00000302176
Q8N568
Show all »
Show » Show » 783 85.4 No 0
DCLK2-004 ENSP00000427235
ENST00000506325
Q8N568
Show all »
Show » Show » 765 83.5 No 0