KRT8

GENE INFORMATION

? »

Gene name

KRT8 (HGNC Symbol)

Synonyms

CARD2, CK8, CYK8, K2C8, K8, KO

Description

keratin 8 (HGNC Symbol)

Entrez gene summary

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

12 (Chromosome progress)

Cytoband

q13.13

Chromosome location (bp)

53290977 - 53343738

Ensembl

ENSG00000170421 (version 73.37)

Entrez gene

3856

UniProt

P05787 (UniProt - Evidence at protein level)

neXtProt

NX_P05787

Antibodypedia

KRT8 antibodies
 

PROTEIN VIEW

? »
 
 
 
KRT8-001
 
KRT8-002
 
KRT8-003
 
KRT8-004
 
KRT8-013
 
KRT8-014
 
KRT8-015
 
KRT8-016
 
KRT8-017
 
KRT8-019
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KRT8-001 ENSP00000447566
ENST00000552551
P05787
Show all »
Show » Show » 483 53.7 No 0
KRT8-002 ENSP00000293308
ENST00000293308
P05787
Show all »
Show » Show » 483 53.7 No 0
KRT8-003 ENSP00000447402
ENST00000546897
P05787
Show all »
Show » Show » 483 53.7 No 0
KRT8-004 ENSP00000449404
ENST00000552150
P05787
Show all »
Show » Show » 511 56.6 No 0
KRT8-013 ENSP00000447881
ENST00000546826
F8VUG2
Show all »
Show » 273 30.9 No 0
KRT8-014 ENSP00000447040
ENST00000548998
F8W1U3
Show all »
Show » 289 32.5 No 0
KRT8-015 ENSP00000450228
ENST00000546542
F8VQY3
Show all »
Show » 180 19.1 No 0
KRT8-016 ENSP00000448681
ENST00000547413
F8VRG4
Show all »
Show » 177 19.6 No 0
KRT8-017 ENSP00000450340
ENST00000546900
F8VP67
Show all »
Show » 113 13.6 No 0
KRT8-019 ENSP00000449010
ENST00000547176
H0YIB2
Show all »
Show » 83 8.9 No 0