KRT86

GENE INFORMATION

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Gene name

KRT86 (HGNC Symbol)

Synonyms

Hb6, KRTHB6, MNX

Description

Keratin 86 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q13.13

Chromosome location (bp)

52643084 - 52702947

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170442 (version 75.37)

Entrez gene

3892

UniProt

O43790 (UniProt - Evidence at protein level)

neXtProt

NX_O43790

Antibodypedia

KRT86 antibodies
 

PROTEIN VIEW

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KRT86-001
 
KRT86-002
 
KRT86-201
 
KRT86-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KRT86-001 ENSP00000444533
ENST00000423955
O43790
Show all »
Show » Show » 486 53.5 No 0
KRT86-002 ENSP00000452237
ENST00000553310
U3KPR1
Show all »
Show » Show » 143 15.4 No 0
KRT86-201 ENSP00000293525
ENST00000293525
O43790
Show all »
Show » Show » 486 53.5 No 0
KRT86-202 ENSP00000443169
ENST00000544024
O43790
Show all »
Show » Show » 486 53.5 No 0