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GENE INFORMATION

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Gene name

AC021066.1

Synonyms

Description

keratin, type II cuticular Hb6 (RefSeq peptide)

Entrez gene summary

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]

Chromosome

12 (Chromosome progress)

Cytoband

q13.13

Chromosome location (bp)

52643084 - 52702947

Ensembl

ENSG00000170442 (version 69.37)

Entrez gene

3892

UniProt

neXtProt

Antibodypedia

AC021066.1 antibodies
 

PROTEIN VIEW

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AC021066.1-201
 
AC021066.1-202
 
AC021066.1-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AC021066.1-201 ENSP00000443169
ENST00000544024
Q9NSB0
Show all »
Show » 486 53.5 No 0
AC021066.1-202 ENSP00000444533
ENST00000423955
Q9NSB0
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Show » 486 53.5 No 0
AC021066.1-203 ENSP00000293525
ENST00000293525
Q9NSB0
Show all »
Show » 486 53.5 No 0