HARS

GENERAL INFORMATION

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Gene name

HARS

Gene description

Histidyl-tRNA synthetase

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA036539
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

HARS

Synonyms

Description

Histidyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

5

Cytoband

q31.3

Chromosome location (bp)

140673173 - 140692024

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170445 (version 78.38)

Entrez gene

3035

UniProt

P12081 (UniProt - Evidence at protein level)

neXtProt

NX_P12081

Antibodypedia

HARS antibodies


PROTEIN BROWSER

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ENST00000307633
 
ENST00000415192
 
ENST00000431330
 
ENST00000438307
 
ENST00000457527
 
ENST00000504156
 
ENST00000504366
 
ENST00000507746
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HARS-001 ENSP00000425634
ENST00000504156
P12081
Show all »
Show » Show » 509 57.4 No 0
HARS-003 ENSP00000430063
ENST00000504366
B3KWE1
Show all »
Show » Show » 440 49.6 No 0
HARS-005 ENSP00000393244
ENST00000431330
B4E1C5
Show all »
Show » Show » 395 43.9 No 0
HARS-006 ENSP00000425889
ENST00000507746
E7ETE2
Show all »
Show » Show » 288 31.9 No 0
HARS-008 ENSP00000304668
ENST00000307633
P12081
Show all »
Show » Show » 449 50.2 No 0
HARS-009 ENSP00000387893
ENST00000457527
P12081
Show all »
Show » Show » 489 54.8 No 0
HARS-011 ENSP00000411085
ENST00000415192
B4DDD8
Show all »
Show » Show » 435 48.6 No 0
HARS-012 ENSP00000411511
ENST00000438307
P12081
Show all »
Show » Show » 469 52.7 No 0