HARS

GENE INFORMATION

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Gene name

HARS

Synonyms

Description

histidyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

5 (Chromosome progress)

Cytoband

q31.3

Chromosome location (bp)

140052758 - 140071609

Ensembl

ENSG00000170445 (version 73.37)

Entrez gene

3035

UniProt

P12081 (UniProt - Evidence at protein level)

neXtProt

NX_P12081

Antibodypedia

HARS antibodies
 

PROTEIN VIEW

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HARS-001
 
HARS-003
 
HARS-005
 
HARS-006
 
HARS-008
 
HARS-009
 
HARS-011
 
HARS-012
 
HARS-014
 
HARS-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HARS-001 ENSP00000425634
ENST00000504156
P12081
Show all »
Show » Show » 509 57.4 No 0
HARS-003 ENSP00000430063
ENST00000504366
B3KWE1
Show all »
Show » 440 49.6 No 0
HARS-005 ENSP00000393244
ENST00000431330
B4E1C5
Show all »
Show » 395 43.9 No 0
HARS-006 ENSP00000425889
ENST00000507746
E7ETE2
Show all »
Show » 288 31.9 No 0
HARS-008 ENSP00000304668
ENST00000307633
P12081
Show all »
Show » Show » 449 50.2 No 0
HARS-009 ENSP00000387893
ENST00000457527
P12081
Show all »
Show » Show » 489 54.8 No 0
HARS-011 ENSP00000411085
ENST00000415192
B4DDD8
Show all »
Show » 435 48.6 No 0
HARS-012 ENSP00000411511
ENST00000438307
P12081
Show all »
Show » Show » 469 52.7 No 0
HARS-014 ENSP00000421576
ENST00000512396
D6RF05
Show all »
Show » 60 6.7 No 0
HARS-201 ENSP00000413605
ENST00000448240
C9JWK3
Show all »
Show » 314 35.1 No 0