SLC26A5

GENERAL INFORMATION

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Gene name

SLC26A5

Gene description

Solute carrier family 26 (anion exchanger), member 5

Protein class

Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

10
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Not detected
GTEx:Mixed

Protein evidence

Evidence at transcript level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Not detected

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

SLC26A5 (HGNC Symbol)

Synonyms

DFNB61, PRES

Description

Solute carrier family 26 (anion exchanger), member 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]

Chromosome

7

Cytoband

q22.1

Chromosome location (bp)

103352730 - 103446177

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000170615 (version 78.38)

Entrez gene

375611

UniProt

P58743 (UniProt - Evidence at transcript level)

neXtProt

NX_P58743

Antibodypedia

SLC26A5 antibodies


PROTEIN BROWSER

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ENST00000306312
 
ENST00000339444
 
ENST00000354356
 
ENST00000356767
 
ENST00000393723
 
ENST00000393727
 
ENST00000393729
 
ENST00000393730
 
ENST00000393735
 
ENST00000432958
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC26A5-001 ENSP00000304783
ENST00000306312
P58743
Show all »
Show » Show » 744 81.3 No >9
SLC26A5-002 ENSP00000342396
ENST00000339444
P58743
Show all »
Show » Show » 685 74.8 No >9
SLC26A5-003 ENSP00000349210
ENST00000356767
P58743
Show all »
Show » Show » 335 36.9 No 7
SLC26A5-004 ENSP00000377336
ENST00000393735
P58743
Show all »
Show » Show » 516 56.5 No >9
SLC26A5-008 ENSP00000377331
ENST00000393730
P58743
Show all »
Show » Show » 712 77.6 No >9
SLC26A5-009 ENSP00000377328
ENST00000393727
Q7Z7F4
Show all »
Show » Show » 746 81.5 No >9
SLC26A5-010 ENSP00000377324
ENST00000393723
P58743
Show all »
Show » Show » 714 77.8 No >9
SLC26A5-013 ENSP00000377330
ENST00000393729
E9PCM2
Show all »
Show » Show » 707 77.2 No 9
SLC26A5-201 ENSP00000346325
ENST00000354356
Q7Z7F4
Show all »
Show » Show » 746 81.5 No >9
SLC26A5-202 ENSP00000389733
ENST00000432958
P58743
Show all »
Show » Show » 712 77.6 No >9