SOCS6

GENE INFORMATION

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Gene name

SOCS6 (HGNC Symbol)

Synonyms

CIS4, Cish4, HSPC060, SOCS4, SSI4, STAI4, STATI4

Description

Suppressor of cytokine signaling 6 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]

Chromosome

18

Cytoband

q22.2

Chromosome location (bp)

67956137 - 67997436

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170677 (version 75.37)

Entrez gene

9306

UniProt

O14544 (UniProt - Evidence at protein level)

neXtProt

NX_O14544

Antibodypedia

SOCS6 antibodies
 

PROTEIN VIEW

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SOCS6-001
 
SOCS6-002
 
SOCS6-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOCS6-001 ENSP00000381034
ENST00000397942
O14544
Show all »
Show » Show » 535 59.5 No 0
SOCS6-002 ENSP00000463395
ENST00000582322
O14544
Show all »
Show » Show » 535 59.5 No 0
SOCS6-003 ENSP00000463064
ENST00000578377
J3KTM7
Show all »
Show » Show » 227 25 No 0