SOCS6

GENERAL INFORMATION

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Gene name

SOCS6

Gene description

Suppressor of cytokine signaling 6

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues showed weak to moderate cytoplasmic positivity. Strong immunoreactivity was observed in glandular cells of appendix, placental trophoblasts, Purkinje cells and subsets of renal tubules. Other cells in the CNS were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB010189
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SOCS6 (HGNC Symbol)

Synonyms

CIS4, Cish4, HSPC060, SOCS4, SSI4, STAI4, STATI4

Description

Suppressor of cytokine signaling 6 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]

Chromosome

18

Cytoband

q22.2

Chromosome location (bp)

70288901 - 70330200

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170677 (version 78.38)

Entrez gene

9306

UniProt

O14544 (UniProt - Evidence at protein level)

neXtProt

NX_O14544

Antibodypedia

SOCS6 antibodies


PROTEIN BROWSER

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ENST00000397942
 
ENST00000578377
 
ENST00000582322
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOCS6-001 ENSP00000381034
ENST00000397942
O14544
Show all »
Show » Show » 535 59.5 No 0
SOCS6-002 ENSP00000463395
ENST00000582322
O14544
Show all »
Show » Show » 535 59.5 No 0
SOCS6-003 ENSP00000463064
ENST00000578377
J3KTM7
Show all »
Show » Show » 227 25 No 0