ALK

GENE INFORMATION

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Gene name

ALK (HGNC Symbol)

Synonyms

CD246

Description

anaplastic lymphoma receptor tyrosine kinase (HGNC Symbol)

Entrez gene summary

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

Chromosome

2 (Chromosome progress)

Cytoband

p23.1

Chromosome location (bp)

29415640 - 30144432

Ensembl

ENSG00000171094 (version 73.37)

Entrez gene

238

UniProt

Q9UM73 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UM73

Antibodypedia

ALK antibodies
 

PROTEIN VIEW

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ALK-001
 
ALK-002
 
ALK-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALK-001 ENSP00000373700
ENST00000389048
Q9UM73
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Show » Show » 1620 176.4 Yes 1
ALK-002 ENSP00000387488
ENST00000453137
H7BZ33
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Show » Show » 152 16.9 No 0
ALK-201 ENSP00000414027
ENST00000431873
E7EPW7
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Show » 450 48.3 Yes 0