PRKCE

GENE INFORMATION

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Gene name

PRKCE

Synonyms

Description

protein kinase C, epsilon (HGNC Symbol)

Entrez gene summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

p21

Chromosome location (bp)

45878484 - 46415129

Ensembl

ENSG00000171132 (version 73.37)

Entrez gene

5581

UniProt

Q02156 (UniProt - Evidence at protein level)

neXtProt

NX_Q02156

Antibodypedia

PRKCE antibodies
 

PROTEIN VIEW

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PRKCE-001
 
PRKCE-006
 
PRKCE-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKCE-001 ENSP00000306124
ENST00000306156
Q02156
Show all »
Show » Show » 737 83.7 No 0
PRKCE-006 ENSP00000394574
ENST00000421201
C9JR22
Show all »
Show » 127 14.4 No 0
PRKCE-008 ENSP00000378341
ENST00000394874
E9PBI2
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Show » 219 23.9 No 0