TADA3

GENE INFORMATION

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Gene name

TADA3 (HGNC Symbol)

Synonyms

ADA3, FLJ20221, FLJ21329, hADA3, NGG1, TADA3L

Description

Transcriptional adaptor 3 (HGNC Symbol)

Entrez gene summary

DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Chromosome

3

Cytoband

p25.3

Chromosome location (bp)

9821544 - 9834695

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171148 (version 75.37)

Entrez gene

10474

UniProt

O75528 (UniProt - Evidence at protein level)

neXtProt

NX_O75528

Antibodypedia

TADA3 antibodies
 

PROTEIN VIEW

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TADA3-001
 
TADA3-002
 
TADA3-004
 
TADA3-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TADA3-001 ENSP00000307684
ENST00000301964
O75528
Show all »
Show » Show » 432 48.9 No 0
TADA3-002 ENSP00000343649
ENST00000343450
O75528
Show all »
Show » Show » 369 41.4 No 0
TADA3-004 ENSP00000393471
ENST00000440161
O75528
Show all »
Show » Show » 432 48.9 No 0
TADA3-009 ENSP00000395073
ENST00000439043
C9JMS0
Show all »
Show » Show » 95 10.9 No 0