PTGER4

GENE INFORMATION

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Gene name

PTGER4 (HGNC Symbol)

Synonyms

EP4

Description

Prostaglandin E receptor 4 (subtype EP4) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

p13.1

Chromosome location (bp)

40679600 - 40693837

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171522 (version 75.37)

Entrez gene

5734

UniProt

P35408 (UniProt - Evidence at protein level)

neXtProt

NX_P35408

Antibodypedia

PTGER4 antibodies
 

PROTEIN VIEW

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PTGER4-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTGER4-001 ENSP00000302846
ENST00000302472
P35408
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