PTGER4

GENERAL INFORMATION

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Gene name

PTGER4

Gene description

Prostaglandin E receptor 4 (subtype EP4)

Protein class

FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in all tissues at variable levels. High expression in most glandular epithelia and in CNS.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA011226 , HPA012756
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

PTGER4 (HGNC Symbol)

Synonyms

EP4

Description

Prostaglandin E receptor 4 (subtype EP4) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

p13.1

Chromosome location (bp)

40679498 - 40693735

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171522 (version 78.38)

Entrez gene

5734

UniProt

P35408 (UniProt - Evidence at protein level)

neXtProt

NX_P35408

Antibodypedia

PTGER4 antibodies


PROTEIN BROWSER

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ENST00000302472
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTGER4-001 ENSP00000302846
ENST00000302472
P35408
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