ECEL1

GENE INFORMATION

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Gene name

ECEL1 (HGNC Symbol)

Synonyms

DINE, XCE

Description

endothelin converting enzyme-like 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the M13 family of endopeptidases. In general, M13 family members are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. This gene is expressed specifically in the central nervous system and its protein localizes predominately to the endoplasmic reticulum or, in trace amounts, to the cell surface. Disruption of this gene in mouse embryonic stem cells results in neonatal lethality due to respiratory failure shortly after birth. Based on the specific expression of this gene and the phenotype of the gene deficiency in mouse embryos, it is suggested that this protein plays a critical role in neural regulation of the respiratory system. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

q37.1

Chromosome location (bp)

233344537 - 233352538

Ensembl

ENSG00000171551 (version 73.37)

Entrez gene

9427

UniProt

O95672 (UniProt - Evidence at protein level)

neXtProt

NX_O95672

Antibodypedia

ECEL1 antibodies
 

PROTEIN VIEW

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ECEL1-001
 
ECEL1-003
 
ECEL1-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ECEL1-001 ENSP00000302051
ENST00000304546
O95672
Show all »
Show » Show » 775 87.8 No 1
ECEL1-003 ENSP00000386333
ENST00000409941
O95672
Show all »
Show » Show » 773 87.6 No 1
ECEL1-005 ENSP00000412683
ENST00000411860
H7C3M0
Show all »
Show » 168 19.8 No 0