BCL2L1

GENE INFORMATION

? »

Gene name

BCL2L1 (HGNC Symbol)

Synonyms

Bcl-X, bcl-xL, bcl-xS, BCL2L, BCLX, PPP1R52

Description

BCL2-like 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]

Chromosome

20 (Chromosome progress)

Cytoband

q11.21

Chromosome location (bp)

30252255 - 30311792

Ensembl

ENSG00000171552 (version 73.37)

Entrez gene

598

UniProt

Q07817 (UniProt - Evidence at protein level)

neXtProt

NX_Q07817

Antibodypedia

BCL2L1 antibodies
 

PROTEIN VIEW

? »
 
 
 
BCL2L1-001
 
BCL2L1-002
 
BCL2L1-003
 
BCL2L1-004
 
BCL2L1-005
 
BCL2L1-006
 
BCL2L1-007
 
BCL2L1-008
 
BCL2L1-009
 
BCL2L1-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL2L1-001 ENSP00000365230
ENST00000376062
Q07817
Show all »
Show » Show » 233 26 No 2
BCL2L1-002 ENSP00000365223
ENST00000376055
Q07817
Show all »
Show » Show » 170 18.9 No 1
BCL2L1-003 ENSP00000406203
ENST00000450273
Q5TE64
Show all »
Show » Show » 205 22.9 No 0
BCL2L1-004 ENSP00000302564
ENST00000307677
Q07817
Show all »
Show » Show » 233 26 No 2
BCL2L1-005 ENSP00000389688
ENST00000439267
Q5QP56
Show all »
Show » Show » 181 20.2 No 0
BCL2L1-006 ENSP00000390760
ENST00000420488
Q9H1R6
Show all »
Show » Show » 188 21 No 0
BCL2L1-007 ENSP00000395545
ENST00000456404
Q9H1R6
Show all »
Show » Show » 188 21 No 0
BCL2L1-008 ENSP00000411252
ENST00000422920
Q9H1R6
Show all »
Show » Show » 188 21 No 0
BCL2L1-009 ENSP00000401173
ENST00000434194
Q5QP59
Show all »
Show » 48 5.5 No 0
BCL2L1-201 ENSP00000405563
ENST00000420653
Q07817
Show all »
Show » Show » 233 26 No 2