FGG

GENE INFORMATION

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Gene name

FGG

Synonyms

Description

fibrinogen gamma chain (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

q31.3

Chromosome location (bp)

155525286 - 155534119

Ensembl

ENSG00000171557 (version 73.37)

Entrez gene

2266

UniProt

P02679 (UniProt - Evidence at protein level)

neXtProt

NX_P02679

Antibodypedia

FGG antibodies
 

PROTEIN VIEW

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FGG-001
 
FGG-002
 
FGG-006
 
FGG-007
 
FGG-008
 
FGG-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGG-001 ENSP00000384860
ENST00000404648
P02679
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Show » Show » 437 49.5 Yes 0
FGG-002 ENSP00000336829
ENST00000336098
P02679
Show all »
Show » Show » 453 51.5 Yes 0
FGG-006 ENSP00000384101
ENST00000405164
C9JEU5
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Show » Show » 445 50.3 Yes 0
FGG-007 ENSP00000384552
ENST00000407946
C9JC84
Show all »
Show » Show » 461 52.3 Yes 0
FGG-008 ENSP00000407562
ENST00000443553
C9JU00
Show all »
Show » 123 14 No 0
FGG-009 ENSP00000377429
ENST00000393846
C9JPQ9
Show all »
Show » 119 13.5 No 0