FGA

GENE INFORMATION

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Gene name

FGA

Synonyms

Description

fibrinogen alpha chain (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

q31.3

Chromosome location (bp)

155504278 - 155511918

Ensembl

ENSG00000171560 (version 73.37)

Entrez gene

2243

UniProt

P02671 (UniProt - Evidence at protein level)

neXtProt

NX_P02671

Antibodypedia

FGA antibodies
 

PROTEIN VIEW

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FGA-001
 
FGA-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGA-001 ENSP00000385981
ENST00000403106
P02671
Show all »
Show » Show » 644 69.8 Yes 0
FGA-002 ENSP00000306361
ENST00000302053
P02671
Show all »
Show » Show » 866 95 Yes 0