FGB

GENERAL INFORMATION

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Gene name

FGB

Gene description

Fibrinogen beta chain

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in hepatocytes, and strong positivity in plasma and extracellular compartments.

ANTIBODY RELIABILITY

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Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Data reliability

Supportive based on 3 antibodies.
HPA001900 , HPA001901 , CAB008624
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression



GENE INFORMATION

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Gene name

FGB

Synonyms

Description

Fibrinogen beta chain (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Chromosome

4

Cytoband

q31.3

Chromosome location (bp)

154562956 - 154571086

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171564 (version 78.38)

Entrez gene

2244

UniProt

P02675 (UniProt - Evidence at protein level)

neXtProt

NX_P02675

Antibodypedia

FGB antibodies


PROTEIN BROWSER

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ENST00000302068
 
ENST00000509493
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGB-001 ENSP00000306099
ENST00000302068
P02675
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Show » Show » 491 55.9 Yes 0
FGB-010 ENSP00000426757
ENST00000509493
D6REL8
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Show » 272 31.2 No 0