FGB

GENE INFORMATION

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Gene name

FGB

Synonyms

Description

fibrinogen beta chain (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

q31.3

Chromosome location (bp)

155484108 - 155492238

Ensembl

ENSG00000171564 (version 73.37)

Entrez gene

2244

UniProt

P02675 (UniProt - Evidence at protein level)

neXtProt

NX_P02675

Antibodypedia

FGB antibodies
 

PROTEIN VIEW

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FGB-001
 
FGB-003
 
FGB-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGB-001 ENSP00000306099
ENST00000302068
P02675
Show all »
Show » Show » 491 55.9 Yes 0
FGB-003 ENSP00000398719
ENST00000425838
F8W6P4
Show all »
Show » 45 5.4 Yes 0
FGB-010 ENSP00000426757
ENST00000509493
D6REL8
Show all »
Show » 272 31.2 No 0