P2RY6

GENERAL INFORMATION

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Gene name

P2RY6

Gene description

Pyrimidinergic receptor P2Y, G-protein coupled, 6

Protein class

G-protein coupled receptors
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

12
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (placenta, spleen)
GTEx:Tissue enriched (spleen)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in spleen and placenta. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
CAB022740
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (placenta, spleen)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (spleen)

Organ

Expression



GENE INFORMATION

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Gene name

P2RY6 (HGNC Symbol)

Synonyms

P2Y6

Description

Pyrimidinergic receptor P2Y, G-protein coupled, 6 (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]

Chromosome

11

Cytoband

q13.4

Chromosome location (bp)

73264505 - 73298617

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171631 (version 78.38)

Entrez gene

5031

UniProt

Q15077 (UniProt - Evidence at protein level)

neXtProt

NX_Q15077

Antibodypedia

P2RY6 antibodies


PROTEIN BROWSER

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ENST00000349767
 
ENST00000393590
 
ENST00000393591
 
ENST00000393592
 
ENST00000535931
 
ENST00000536225
 
ENST00000538328
 
ENST00000540124
 
ENST00000540342
 
ENST00000542092
 
ENST00000544437
 
ENST00000618468
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

P2RY6-001 ENSP00000443427
ENST00000540342
Q15077
Show all »
Show » Show » 328 36.4 No 7
P2RY6-002 ENSP00000445652
ENST00000542092
Q15077
Show all »
Show » Show » 328 36.4 No 7
P2RY6-003 ENSP00000309771
ENST00000349767
Q15077
Show all »
Show » Show » 328 36.4 No 7
P2RY6-004 ENSP00000377217
ENST00000393592
Q15077
Show all »
Show » Show » 328 36.4 No 7
P2RY6-005 ENSP00000377216
ENST00000393591
Q15077
Show all »
Show » Show » 328 36.4 No 7
P2RY6-006 ENSP00000442551
ENST00000540124
Q15077
Show all »
Show » Show » 328 36.4 No 7
P2RY6-007 ENSP00000377215
ENST00000393590
Q15077
Show all »
Show » Show » 328 36.4 No 7
P2RY6-008 ENSP00000442990
ENST00000538328
Q15077
Show all »
Show » Show » 328 36.4 No 7
P2RY6-009 ENSP00000441079
ENST00000544437
F5GX90
Show all »
Show » Show » 128 14.3 No 3
P2RY6-010 ENSP00000442509
ENST00000536225
F5H7H9
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Show » Show » 56 6.2 No 1
P2RY6-011 ENSP00000440770
ENST00000535931
F5GYF3
Show all »
Show » Show » 245 27 No 5
P2RY6-201 ENSP00000480966
ENST00000618468
Q15077
Show all »
Show » Show » 328 36.4 No 7