BPTF

GENE INFORMATION

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Gene name

BPTF (HGNC Symbol)

Synonyms

FAC1, FALZ, NURF301

Description

bromodomain PHD finger transcription factor (HGNC Symbol)

Entrez gene summary

This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q24.2

Chromosome location (bp)

65821640 - 65980494

Ensembl

ENSG00000171634 (version 73.37)

Entrez gene

2186

UniProt

Q12830 (UniProt - Evidence at protein level)

neXtProt

NX_Q12830

Antibodypedia

BPTF antibodies
 

PROTEIN VIEW

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BPTF-001
 
BPTF-002
 
BPTF-004
 
BPTF-005
 
BPTF-006
 
BPTF-009
 
BPTF-010
 
BPTF-011
 
BPTF-017
 
BPTF-018
 
BPTF-201
 
BPTF-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BPTF-001 ENSP00000388405
ENST00000424123
E7ETD6
Show all »
Show » Show » 2764 308.1 No 0
BPTF-002 ENSP00000307208
ENST00000306378
Q12830
Show all »
Show » Show » 2920 325.1 No 0
BPTF-004 ENSP00000463845
ENST00000581258
Show » 420 48.3 No 0
BPTF-005 ENSP00000462535
ENST00000580465
Show » 484 52.5 No 0
BPTF-006 ENSP00000343837
ENST00000342579
Q86TN2
Show all »
Show » 650 72.5 No 0
BPTF-009 ENSP00000440854
ENST00000544778
F5GXF5
Show all »
Show » 2457 271.5 No 0
BPTF-010 ENSP00000463776
ENST00000582467
339 35.7 No 0
BPTF-011 ENSP00000443949
ENST00000544491
137 14.7 No 0
BPTF-017 ENSP00000463736
ENST00000583990
Show » 69 7.8 No 0
BPTF-018 ENSP00000462703
ENST00000577837
Show » 64 7.6 No 0
BPTF-201 ENSP00000315454
ENST00000321892
Q12830
Show all »
Show » Show » 3046 338.3 No 0
BPTF-202 ENSP00000334351
ENST00000335221
Q12830
Show all »
Show » Show » 2903 322.2 No 0