BCL2

GENE INFORMATION

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Gene name

BCL2 (HGNC Symbol)

Synonyms

Bcl-2, PPP1R50

Description

B-cell CLL/lymphoma 2 (HGNC Symbol)

Entrez gene summary

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]

Chromosome

18 (Chromosome progress)

Cytoband

q21.33

Chromosome location (bp)

60790579 - 60987361

Ensembl

ENSG00000171791 (version 73.37)

Entrez gene

596

UniProt

P10415 (UniProt - Evidence at protein level)

neXtProt

NX_P10415

Antibodypedia

BCL2 antibodies
 

PROTEIN VIEW

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BCL2-001
 
BCL2-002
 
BCL2-003
 
BCL2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL2-001 ENSP00000381185
ENST00000398117
P10415
Show all »
Show » Show » 239 26.3 No 2
BCL2-002 ENSP00000329623
ENST00000333681
P10415
Show all »
Show » Show » 239 26.3 No 2
BCL2-003 ENSP00000466417
ENST00000589955
C9JHD5
Show all »
Show » Show » 205 22.3 No 0
BCL2-201 ENSP00000404214
ENST00000444484
C9JHD5
Show all »
Show » Show » 205 22.3 No 0