PTEN

GENE INFORMATION

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Gene name

PTEN (HGNC Symbol)

Synonyms

BZS, MHAM, MMAC1, PTEN1, TEP1

Description

phosphatase and tensin homolog (HGNC Symbol)

Entrez gene summary

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

q23.31

Chromosome location (bp)

89622870 - 89731687

Ensembl

ENSG00000171862 (version 73.37)

Entrez gene

5728

UniProt

P60484 (UniProt - Evidence at protein level)

neXtProt

NX_P60484

Antibodypedia

PTEN antibodies
 

PROTEIN VIEW

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PTEN-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTEN-001 ENSP00000361021
ENST00000371953
P60484
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