AQP4 is the most prevalent aquaporin channel in the CNS with a most common localisation in the astrocytic end-feet. Its RNA is highly and widely expressed across many regions of the human and mouse brain. Moreover, strong intensity and widespread immunolabelling of astrocyte end-feet is noticed throughout the entire mouse brain with this pattern depicting the vasculature (capillary walls) as well.
Positive cells and structuresi
Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain.