LAMB2

GENE INFORMATION

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Gene name

LAMB2 (HGNC Symbol)

Synonyms

LAMS

Description

laminin, beta 2 (laminin S) (HGNC Symbol)

Entrez gene summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known. [provided by RefSeq, Aug 2011]

Chromosome

3 (Chromosome progress)

Cytoband

p21.31

Chromosome location (bp)

49158547 - 49170551

Ensembl

ENSG00000172037 (version 73.37)

Entrez gene

3913

UniProt

P55268 (UniProt - Evidence at protein level)

neXtProt

NX_P55268

Antibodypedia

LAMB2 antibodies
 

PROTEIN VIEW

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LAMB2-001
 
LAMB2-003
 
LAMB2-018
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LAMB2-001 ENSP00000388325
ENST00000418109
P55268
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Show » Show » 1798 196 Yes 0
LAMB2-003 ENSP00000307156
ENST00000305544
P55268
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Show » Show » 1798 196 Yes 0
LAMB2-018 ENSP00000444751
ENST00000494831
F5H520
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Show » 151 17.3 No 0