EIF2AK3

GENE INFORMATION

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Gene name

EIF2AK3 (HGNC Symbol)

Synonyms

PEK, PERK

Description

eukaryotic translation initiation factor 2-alpha kinase 3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010]

Chromosome

2 (Chromosome progress)

Cytoband

p11.2

Chromosome location (bp)

88856259 - 88927094

Ensembl

ENSG00000172071 (version 73.37)

Entrez gene

9451

UniProt

Q9NZJ5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NZJ5

Antibodypedia

EIF2AK3 antibodies
 

PROTEIN VIEW

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EIF2AK3-001
 
EIF2AK3-003
 
EIF2AK3-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EIF2AK3-001 ENSP00000307235
ENST00000303236
Q9NZJ5
Show all »
Show » Show » 1116 125.2 Yes 2
EIF2AK3-003 ENSP00000408325
ENST00000419748
E7ER02
Show all »
Show » Show » 965 109.9 No 2
EIF2AK3-004 ENSP00000412076
ENST00000415570
C9J185
Show all »
Show » Show » 956 108.9 No 2