ADRBK1

GENE INFORMATION

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Gene name

ADRBK1 (HGNC Symbol)

Synonyms

BARK1, GRK2

Description

adrenergic, beta, receptor kinase 1 (HGNC Symbol)

Entrez gene summary

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

67033881 - 67054027

Ensembl

ENSG00000173020 (version 73.37)

Entrez gene

156

UniProt

P25098 (UniProt - Evidence at protein level)

neXtProt

NX_P25098

Antibodypedia

ADRBK1 antibodies
 

PROTEIN VIEW

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ADRBK1-001
 
ADRBK1-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADRBK1-001 ENSP00000312262
ENST00000308595
P25098
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Show » Show » 689 79.6 No 0
ADRBK1-011 ENSP00000434126
ENST00000526285
E9PRV7
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Show » 408 46.5 No 0