ADCY5

GENERAL INFORMATION

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Gene name

ADCY5

Gene description

Adenylate cyclase 5

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (heart muscle)
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal cells displayed weak cytoplasmic staining or were negative. The urinary bladder showed strong membranous staining while cilia were strongly stained in fallopian tube and airway epithelia. Seminal vesicle and placenta displayed moderate cytoplasmic staining.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA017730
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (heart muscle)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ADCY5 (HGNC Symbol)

Synonyms

AC5

Description

Adenylate cyclase 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Chromosome

3

Cytoband

q21.1

Chromosome location (bp)

123282296 - 123449758

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173175 (version 78.38)

Entrez gene

111

UniProt

O95622 (UniProt - Evidence at protein level)

neXtProt

NX_O95622

Antibodypedia

ADCY5 antibodies


PROTEIN BROWSER

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ENST00000309879
 
ENST00000462833
 
ENST00000466617
 
ENST00000483566
 
ENST00000491190
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADCY5-001 ENSP00000419361
ENST00000462833
O95622
Show all »
Show » Show » 1261 138.9 No >9
ADCY5-002 ENSP00000418537
ENST00000491190
B3KWA8
Show all »
Show » Show » 919 103.9 No 7
ADCY5-003 ENSP00000308685
ENST00000309879
O95622
Show all »
Show » Show » 911 102.6 No 7
ADCY5-004 ENSP00000420082
ENST00000466617
C9JRT8
Show all »
Show » Show » 492 55.5 No 4
ADCY5-005 ENSP00000420252
ENST00000483566
C9JQ38
Show all »
Show » Show » 90 10.3 No 0