CYSLTR1

GENE INFORMATION

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Gene name

CYSLTR1 (HGNC Symbol)

Synonyms

CysLT(1), CysLT1, CYSLT1R

Description

cysteinyl leukotriene receptor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

X (Chromosome progress)

Cytoband

q21.1

Chromosome location (bp)

77526961 - 77583048

Ensembl

ENSG00000173198 (version 73.37)

Entrez gene

10800

UniProt

Q9Y271 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9Y271

Antibodypedia

CYSLTR1 antibodies
 

PROTEIN VIEW

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CYSLTR1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYSLTR1-001 ENSP00000362401
ENST00000373304
Q9Y271
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