MAP3K11

GENE INFORMATION

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Gene name

MAP3K11 (HGNC Symbol)

Synonyms

MEKK11, MLK3, PTK1, SPRK

Description

mitogen-activated protein kinase kinase kinase 11 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q13.1

Chromosome location (bp)

65365226 - 65382853

Ensembl

ENSG00000173327 (version 73.37)

Entrez gene

4296

UniProt

Q16584 (UniProt - Evidence at protein level)

neXtProt

NX_Q16584

Antibodypedia

MAP3K11 antibodies
 

PROTEIN VIEW

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MAP3K11-001
 
MAP3K11-004
 
MAP3K11-005
 
MAP3K11-006
 
MAP3K11-012
 
MAP3K11-013
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP3K11-001 ENSP00000309597
ENST00000309100
Q16584
Show all »
Show » Show » 847 92.7 No 0
MAP3K11-004 ENSP00000433886
ENST00000530153
B4DS76
Show all »
Show » 590 65.3 No 0
MAP3K11-005 ENSP00000431506
ENST00000524848
H0YCF5
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Show » 215 22.5 No 0
MAP3K11-006 ENSP00000432068
ENST00000532507
E9PID4
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Show » 263 27.6 No 0
MAP3K11-012 ENSP00000435970
ENST00000526293
E9PRQ2
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Show » Show » 111 12.3 No 0
MAP3K11-013 ENSP00000435237
ENST00000529839
E9PLB1
Show all »
Show » Show » 97 10.7 No 0