DAG1

GENE INFORMATION

? »

Gene name

DAG1 (HGNC Symbol)

Synonyms

156DAG, A3a, AGRNR, DAG

Description

dystroglycan 1 (dystrophin-associated glycoprotein 1) (HGNC Symbol)

Entrez gene summary

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.[provided by RefSeq, Apr 2010]

Chromosome

3 (Chromosome progress)

Cytoband

p21.31

Chromosome location (bp)

49506146 - 49573048

Ensembl

ENSG00000173402 (version 73.37)

Entrez gene

1605

UniProt

Q14118 (UniProt - Evidence at protein level)

neXtProt

NX_Q14118

Antibodypedia

DAG1 antibodies
 

PROTEIN VIEW

? »
 
 
 « 
 
DAG1-001
 
DAG1-003
 
DAG1-004
 
DAG1-005
 
DAG1-006
 
DAG1-007
 
DAG1-009
 
DAG1-011
 
DAG1-012
 
DAG1-015
 
DAG1-201
 
DAG1-202
 
DAG1-203
 
DAG1-204
 
DAG1-205
 
 » 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DAG1-001 ENSP00000312435
ENST00000308775
Q14118
Show all »
Show » Show » 895 97.4 Yes 1
DAG1-003 ENSP00000412067
ENST00000421560
C9J196
Show all »
Show » 106 11.2 Yes 0
DAG1-004 ENSP00000405859
ENST00000418588
C9J6Z6
Show all »
Show » 88 9.5 Yes 0
DAG1-005 ENSP00000415321
ENST00000435508
C9JEH2
Show all »
Show » Show » 52 5.8 Yes 0
DAG1-006 ENSP00000387859
ENST00000452317
C9JY76
Show all »
Show » Show » 41 4.5 Yes 0
DAG1-007 ENSP00000410145
ENST00000452060
C9JEN1
Show all »
Show » 86 9.4 Yes 0
DAG1-009 ENSP00000401382
ENST00000428779
C9JYS1
Show all »
Show » 96 10.3 Yes 0
DAG1-011 ENSP00000402443
ENST00000419218
15 1.6 No 0
DAG1-012 ENSP00000401805
ENST00000430636
9 1 No 0
DAG1-015 ENSP00000388833
ENST00000431960
C9JQL4
Show all »
Show » 117 12.6 Yes 0
DAG1-201 ENSP00000440705
ENST00000515359
Q14118
Show all »
Show » Show » 895 97.4 Yes 1
DAG1-202 ENSP00000438421
ENST00000538711
Q14118
Show all »
Show » Show » 895 97.4 Yes 1
DAG1-203 ENSP00000439334
ENST00000539901
Q14118
Show all »
Show » Show » 895 97.4 Yes 1
DAG1-204 ENSP00000440590
ENST00000541308
Q14118
Show all »
Show » Show » 895 97.4 Yes 1
DAG1-205 ENSP00000442600
ENST00000545947
Q14118
Show all »
Show » Show » 895 97.4 Yes 1