PTPRM

GENERAL INFORMATION

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Gene name

PTPRM

Gene description

Protein tyrosine phosphatase, receptor type, M

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Granular and sometimes membranous expression at variable levels in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
CAB022442 , CAB022443
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PTPRM (HGNC Symbol)

Synonyms

hR-PTPu, PTPRL1, RPTPU

Description

Protein tyrosine phosphatase, receptor type, M (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Chromosome

18

Cytoband

p11.23

Chromosome location (bp)

7566782 - 8406861

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173482 (version 78.38)

Entrez gene

5797

UniProt

P28827 (UniProt - Evidence at protein level)

neXtProt

NX_P28827

Antibodypedia

PTPRM antibodies


PROTEIN BROWSER

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ENST00000332175
 
ENST00000400053
 
ENST00000400060
 
ENST00000577468
 
ENST00000578916
 
ENST00000580170
 
ENST00000583153
 
ENST00000583289
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPRM-001 ENSP00000331418
ENST00000332175
P28827
Show all »
Show » Show » 1452 163.7 Yes 1
PTPRM-003 ENSP00000382927
ENST00000400053
E7EPS8
Show all »
Show » Show » 1390 157.1 No 1
PTPRM-004 ENSP00000463558
ENST00000578916
J3QLI4
Show all »
Show » Show » 173 18.7 No 0
PTPRM-008 ENSP00000462176
ENST00000583289
Show » Show » 264 28.8 No 1
PTPRM-010 ENSP00000464128
ENST00000577468
J3QRB4
Show all »
Show » 207 23 No 1
PTPRM-012 ENSP00000463325
ENST00000580170
P28827
Show all »
Show » Show » 1465 165.1 Yes 1
PTPRM-016 ENSP00000462809
ENST00000583153
Show » Show » 238 26.5 No 0
PTPRM-201 ENSP00000382933
ENST00000400060
Q49AC9
Show all »
Show » Show » 279 32.3 No 0