PC

GENE INFORMATION

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Gene name

PC (HGNC Symbol)

Synonyms

PCB

Description

pyruvate carboxylase (HGNC Symbol)

Entrez gene summary

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

66615704 - 66725847

Ensembl

ENSG00000173599 (version 73.37)

Entrez gene

5091

UniProt

P11498 (UniProt - Evidence at protein level)

neXtProt

NX_P11498

Antibodypedia

PC antibodies
 

PROTEIN VIEW

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PC-001
 
PC-003
 
PC-005
 
PC-011
 
PC-201
 
PC-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PC-001 ENSP00000377530
ENST00000393958
P11498
Show all »
Show » Show » 1178 129.6 No 0
PC-003 ENSP00000434192
ENST00000524491
E9PRE7
Show all »
Show » 489 53.4 No 0
PC-005 ENSP00000377527
ENST00000393955
P11498
Show all »
Show » Show » 1178 129.6 No 0
PC-011 ENSP00000435905
ENST00000529047
E9PS68
Show all »
Show » 298 32.7 No 0
PC-201 ENSP00000347900
ENST00000355677
B4DN00
Show all »
Show » 529 57.9 No 0
PC-202 ENSP00000377532
ENST00000393960
P11498
Show all »
Show » Show » 1178 129.6 No 0