STAT5B

GENE INFORMATION

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Gene name

STAT5B

Synonyms

Description

signal transducer and activator of transcription 5B (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q21.2

Chromosome location (bp)

40351186 - 40428725

Ensembl

ENSG00000173757 (version 73.37)

Entrez gene

6777

UniProt

P51692 (UniProt - Evidence at protein level)

neXtProt

NX_P51692

Antibodypedia

STAT5B antibodies
 

PROTEIN VIEW

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STAT5B-001
 
STAT5B-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STAT5B-001 ENSP00000293328
ENST00000293328
P51692
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Show » Show » 787 89.9 No 0
STAT5B-003 ENSP00000398379
ENST00000415845
C9J4I3
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Show » Show » 156 18 No 0