TCAP

GENERAL INFORMATION

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Gene name

TCAP

Gene description

Titin-cap

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (heart muscle, skeletal muscle)
GTEx:Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic expression in skeletal and heart muscle.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Data reliability

Supportive based on 2 antibodies.
HPA026477 , CAB004591
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (heart muscle, skeletal muscle)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (heart muscle, skeletal muscle)

Organ

Expression



GENE INFORMATION

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Gene name

TCAP (HGNC Symbol)

Synonyms

CMD1N, LGMD2G, T-cap, TELE, telethonin

Description

Titin-cap (HGNC Symbol)

Entrez gene summary

Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q12

Chromosome location (bp)

39664187 - 39666555

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173991 (version 78.38)

Entrez gene

8557

UniProt

O15273 (UniProt - Evidence at protein level)

neXtProt

NX_O15273

Antibodypedia

TCAP antibodies


PROTEIN BROWSER

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ENST00000309889
 
ENST00000578283
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TCAP-001 ENSP00000312624
ENST00000309889
O15273
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Show » Show » 167 19.1 No 0
TCAP-002 ENSP00000462787
ENST00000578283
J3KT40
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Show » 143 16.2 No 0