TCAP

GENE INFORMATION

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Gene name

TCAP (HGNC Symbol)

Synonyms

CMD1N, LGMD2G, T-cap, TELE, telethonin

Description

titin-cap (HGNC Symbol)

Entrez gene summary

Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

37820440 - 37822808

Ensembl

ENSG00000173991 (version 73.37)

Entrez gene

8557

UniProt

O15273 (UniProt - Evidence at protein level)

neXtProt

NX_O15273

Antibodypedia

TCAP antibodies
 

PROTEIN VIEW

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TCAP-001
 
TCAP-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TCAP-001 ENSP00000312624
ENST00000309889
O15273
Show all »
Show » 167 19.1 No 0
TCAP-002 ENSP00000462787
ENST00000578283
J3KT40
Show all »
143 16.2 No 0