CTSF

GENE INFORMATION

? »

Gene name

CTSF (HGNC Symbol)

Synonyms

CATSF, CLN13

Description

cathepsin F (HGNC Symbol)

Entrez gene summary

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

66330934 - 66336312

Ensembl

ENSG00000174080 (version 73.37)

Entrez gene

8722

UniProt

Q9UBX1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UBX1

Antibodypedia

CTSF antibodies
 

PROTEIN VIEW

? »
 
 
 
CTSF-001
 
CTSF-003
 
CTSF-008
 
CTSF-009
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTSF-001 ENSP00000310832
ENST00000310325
Q9UBX1
Show all »
Show » Show » 484 53.4 Yes 0
CTSF-003 ENSP00000435822
ENST00000526010
E9PSC2
Show all »
Show » 120 13.5 No 0
CTSF-008 ENSP00000434936
ENST00000525733
Show » 82 8.9 No 0
CTSF-009 ENSP00000433082
ENST00000524994
Show » 283 31.8 No 0