MRPL45

GENE INFORMATION

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Gene name

MRPL45 (HGNC Symbol)

Synonyms

MGC11321

Description

mitochondrial ribosomal protein L45 (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 2p and 17q. [provided by RefSeq, May 2013]

Chromosome

17 (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

36452989 - 36479101

Ensembl

ENSG00000174100 (version 73.37)

Entrez gene

84311

UniProt

Q9BRJ2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BRJ2

Antibodypedia

MRPL45 antibodies
 

PROTEIN VIEW

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MRPL45-001
 
MRPL45-002
 
MRPL45-003
 
MRPL45-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRPL45-001 ENSP00000308901
ENST00000312513
Q9BRJ2
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Show » Show » 306 35.4 No 0
MRPL45-002 ENSP00000462622
ENST00000580762
J3KSS2
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165 18 No 0
MRPL45-003 ENSP00000464686
ENST00000582535
J3QSH3
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159 18.2 No 0
MRPL45-004 ENSP00000462875
ENST00000579911
35 4.1 No 0