The Human Protein Atlas

GENE INFORMATION

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Gene name	SELP (HGNC Symbol)
Synonyms	CD62, CD62P, GMP140, GRMP, PADGEM, PSEL
Description	selectin P (granule membrane protein 140kDa, antigen CD62) (HGNC Symbol)
Entrez gene summary	This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]
Chromosome	1 (Chromosome progress)
Cytoband	q24.2
Chromosome location (bp)	169558037 - 169599380
Ensembl	ENSG00000174175 (version 69.37)
Entrez gene	6403
UniProt	P16109
neXtProt	NX_P16109
Antibodypedia	SELP antibodies

PROTEIN VIEW

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SELP-001		SELP-002		SELP-003		SELP-004		SELP-005		SELP-006		SELP-007		SELP-008		SELP-201		SELP-202		SELP-203		SELP-204		SELP-205

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
SELP-001	ENSP00000356764 ENST00000367790	P16109 Show all » « Hide P16109 [Direct mapping] P-selectin Q5R349 [Target identity:99%; Query identity:100%] P-selectin; Selectin P (Granule membrane protein 140kDa, antigen CD62) Q6ULR6 [Target identity:16%; Query identity:100%] P-selectin	Show » « Hide CD markers Candidate cancer biomarkers Plasma proteins Candidate cardiovascular disease genes Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0001530 [lipopolysaccharide binding] GO:0001948 [glycoprotein binding] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0002691 [regulation of cellular extravasation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005625 [soluble fraction] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007157 [heterophilic cell-cell adhesion] GO:0007159 [leukocyte cell-cell adhesion] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0009897 [external side of plasma membrane] GO:0010572 [positive regulation of platelet activation] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] GO:0014070 [response to organic cyclic compound] GO:0016020 [membrane] GO:0016337 [cell-cell adhesion] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0031092 [platelet alpha granule membrane] GO:0032496 [response to lipopolysaccharide] GO:0033623 [regulation of integrin activation] GO:0033691 [sialic acid binding] GO:0042806 [fucose binding] GO:0043208 [glycosphingolipid binding] GO:0043499 [eukaryotic cell surface binding] GO:0045785 [positive regulation of cell adhesion] GO:0048306 [calcium-dependent protein binding] GO:0048514 [blood vessel morphogenesis] GO:0050829 [defense response to Gram-negative bacterium] GO:0050900 [leukocyte migration] GO:0050901 [leukocyte tethering or rolling] GO:0070492 [oligosaccharide binding]	830	90.8	No	1
SELP-002	ENSP00000391694 ENST00000426706	Q5R349 Show all » « Hide Q5R349 [Target identity:100%; Query identity:100%] P-selectin; Selectin P (Granule membrane protein 140kDa, antigen CD62) Q6ULR6 [Target identity:16%; Query identity:100%] P-selectin	Show » « Hide Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM	Show » « Hide GO:0001948 [glycoprotein binding] GO:0002687 [positive regulation of leukocyte migration] GO:0002691 [regulation of cellular extravasation] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006954 [inflammatory response] GO:0007157 [heterophilic cell-cell adhesion] GO:0009897 [external side of plasma membrane] GO:0010572 [positive regulation of platelet activation] GO:0014070 [response to organic cyclic compound] GO:0032496 [response to lipopolysaccharide] GO:0033691 [sialic acid binding] GO:0043499 [eukaryotic cell surface binding] GO:0045785 [positive regulation of cell adhesion] GO:0048306 [calcium-dependent protein binding] GO:0048514 [blood vessel morphogenesis] GO:0050901 [leukocyte tethering or rolling]	829	90.7	No	1
SELP-003	ENSP00000356769 ENST00000367795	Q5R343 Show all » « Hide Q5R343 [Target identity:100%; Query identity:100%] P-selectin; Selectin P (Granule membrane protein 140kDa, antigen CD62) Q6ULR6 [Target identity:21%; Query identity:100%] P-selectin	Show » « Hide Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM	Show » « Hide GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0030246 [carbohydrate binding]	644	70.7	No	1
SELP-004	ENSP00000356763 ENST00000367789	Q5R342 Show all » « Hide Q5R342 [Target identity:100%; Query identity:100%] P-selectin; Selectin P (Granule membrane protein 140kDa, antigen CD62) Q5R350 [Target identity:99%; Query identity:100%] Selectin P (Granule membrane protein 140kDa, antigen CD62) Q6ULR6 [Target identity:21%; Query identity:100%] P-selectin	Show » « Hide Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM	Show » « Hide GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0030246 [carbohydrate binding]	646	70.9	No	1
SELP-005	ENSP00000356760 ENST00000367786	Q5R341 Show all » « Hide Q5R341 [Target identity:100%; Query identity:100%] P-selectin; Selectin P (Granule membrane protein 140kDa, antigen CD62); Selectin P (Granule membrane protein 140kDa, antigen CD62), isoform CRA_a Q5R348 [Target identity:98%; Query identity:100%] P-selectin; Selectin P (Granule membrane protein 140kDa, antigen CD62) Q6ULR6 [Target identity:17%; Query identity:100%] P-selectin	Show » « Hide Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM	Show » « Hide GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0030246 [carbohydrate binding]	768	84	No	1
SELP-006	ENSP00000356762 ENST00000367788	Q5R345 Show all » « Hide Q5R345 [Target identity:100%; Query identity:100%] P-selectin; Selectin P (Granule membrane protein 140kDa, antigen CD62) Q6ULR6 [Target identity:17%; Query identity:100%] P-selectin	Show » « Hide Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM	Show » « Hide GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0030246 [carbohydrate binding]	768	84.3	No	1
SELP-007	ENSP00000399368 ENST00000458599	Q5R348 Show all » « Hide Q5R348 [Target identity:100%; Query identity:100%] P-selectin; Selectin P (Granule membrane protein 140kDa, antigen CD62) Q6ULR6 [Target identity:18%; Query identity:100%] P-selectin	Show » « Hide Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins SignalP predicted secreted proteins	Show » « Hide GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0030246 [carbohydrate binding]	753	82.2	No	1
SELP-008	ENSP00000388683 ENST00000446728	Q5R350 Show all » « Hide Q5R350 [Target identity:99%; Query identity:100%] Selectin P (Granule membrane protein 140kDa, antigen CD62) Q6ULR6 [Target identity:21%; Query identity:100%] P-selectin	Show » « Hide Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM		646	70.8	No	1
SELP-201	ENSP00000263686 ENST00000263686	P16109 Show all » « Hide P16109 [Direct mapping] P-selectin Q5R349 [Target identity:99%; Query identity:100%] P-selectin; Selectin P (Granule membrane protein 140kDa, antigen CD62) Q6ULR6 [Target identity:16%; Query identity:100%] P-selectin	Show » « Hide CD markers Candidate cancer biomarkers Plasma proteins Candidate cardiovascular disease genes Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0001530 [lipopolysaccharide binding] GO:0001948 [glycoprotein binding] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0002691 [regulation of cellular extravasation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005625 [soluble fraction] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007157 [heterophilic cell-cell adhesion] GO:0007159 [leukocyte cell-cell adhesion] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0009897 [external side of plasma membrane] GO:0010572 [positive regulation of platelet activation] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] GO:0014070 [response to organic cyclic compound] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0031092 [platelet alpha granule membrane] GO:0032496 [response to lipopolysaccharide] GO:0033623 [regulation of integrin activation] GO:0033691 [sialic acid binding] GO:0042806 [fucose binding] GO:0043208 [glycosphingolipid binding] GO:0043499 [eukaryotic cell surface binding] GO:0045785 [positive regulation of cell adhesion] GO:0048306 [calcium-dependent protein binding] GO:0048514 [blood vessel morphogenesis] GO:0050829 [defense response to Gram-negative bacterium] GO:0050900 [leukocyte migration] GO:0050901 [leukocyte tethering or rolling] GO:0070492 [oligosaccharide binding]	830	90.8	No	1
SELP-202	ENSP00000356765 ENST00000367791	Q5R343 Show all » « Hide Q5R343 [Target identity:100%; Query identity:100%] P-selectin; Selectin P (Granule membrane protein 140kDa, antigen CD62) Q6ULR6 [Target identity:21%; Query identity:100%] P-selectin	Show » « Hide Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM	Show » « Hide GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0030246 [carbohydrate binding]	644	70.7	No	1
SELP-203	ENSP00000356766 ENST00000367792	Q5R342 Show all » « Hide Q5R342 [Target identity:100%; Query identity:100%] P-selectin; Selectin P (Granule membrane protein 140kDa, antigen CD62) Q5R350 [Target identity:99%; Query identity:100%] Selectin P (Granule membrane protein 140kDa, antigen CD62) Q6ULR6 [Target identity:21%; Query identity:100%] P-selectin	Show » « Hide Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM	Show » « Hide GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0030246 [carbohydrate binding]	646	70.9	No	1
SELP-204	ENSP00000356767 ENST00000367793	Q5R345 Show all » « Hide Q5R345 [Target identity:100%; Query identity:100%] P-selectin; Selectin P (Granule membrane protein 140kDa, antigen CD62) Q6ULR6 [Target identity:17%; Query identity:100%] P-selectin	Show » « Hide Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM	Show » « Hide GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0030246 [carbohydrate binding]	768	84.3	No	1
SELP-205	ENSP00000356768 ENST00000367794	Q5R341 Show all » « Hide Q5R341 [Target identity:100%; Query identity:100%] P-selectin; Selectin P (Granule membrane protein 140kDa, antigen CD62); Selectin P (Granule membrane protein 140kDa, antigen CD62), isoform CRA_a Q5R348 [Target identity:98%; Query identity:100%] P-selectin; Selectin P (Granule membrane protein 140kDa, antigen CD62) Q6ULR6 [Target identity:17%; Query identity:100%] P-selectin	Show » « Hide Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM	Show » « Hide GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0030246 [carbohydrate binding]	768	84	No	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.