LEP

GENE INFORMATION

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Gene name

LEP (HGNC Symbol)

Synonyms

OB, OBS

Description

leptin (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]

Chromosome

7 (Chromosome progress)

Cytoband

q32.1

Chromosome location (bp)

127881337 - 127897681

Ensembl

ENSG00000174697 (version 73.37)

Entrez gene

3952

UniProt

P41159 (UniProt - Evidence at protein level)

neXtProt

NX_P41159

Antibodypedia

LEP antibodies
 

PROTEIN VIEW

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LEP-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LEP-001 ENSP00000312652
ENST00000308868
P41159
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