SH3PXD2B

GENERAL INFORMATION

? »

Gene name

SH3PXD2B

Gene description

SH3 and PX domains 2B

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Normal tissues generally showed moderate cytoplasmic staining. Membranous staining was for example observed in the salivary gland. Fractions of ciliated cells displayed strong immunoreactivity. Liver, kidney, myocytes, neuronal cells and lymphoid tissues were weakly stained or negative.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA036471
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

SH3PXD2B (HGNC Symbol)

Synonyms

FLJ20831, KIAA1295

Description

SH3 and PX domains 2B (HGNC Symbol)

Entrez gene summary

This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome. [provided by RefSeq, Sep 2010]

Chromosome

5

Cytoband

q35.1

Chromosome location (bp)

172325181 - 172454523

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000174705 (version 78.38)

Entrez gene

285590

UniProt

A1X283 (UniProt - Evidence at protein level)

neXtProt

NX_A1X283

Antibodypedia

SH3PXD2B antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000311601
 
ENST00000518522
 
ENST00000519643
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SH3PXD2B-001 ENSP00000309714
ENST00000311601
A1X283
Show all »
Show » Show » 911 101.6 No 0
SH3PXD2B-002 ENSP00000430890
ENST00000519643
G3V144
Show all »
Show » Show » 430 49.2 No 0
SH3PXD2B-004 ENSP00000428076
ENST00000518522
Show » 81 9 No 0