HRAS

GENE INFORMATION

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Gene name

HRAS (HGNC Symbol)

Synonyms

HRAS1

Description

Harvey rat sarcoma viral oncogene homolog (HGNC Symbol)

Entrez gene summary

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

p15.5

Chromosome location (bp)

532242 - 537287

Ensembl

ENSG00000174775 (version 73.37)

Entrez gene

3265

UniProt

P01112 (UniProt - Evidence at protein level)

neXtProt

NX_P01112

Antibodypedia

HRAS antibodies
 

PROTEIN VIEW

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HRAS-001
 
HRAS-002
 
HRAS-004
 
HRAS-009
 
HRAS-201
 
HRAS-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HRAS-001 ENSP00000434023
ENST00000493230
P01112
Show all »
Show » Show » 170 18.9 No 0
HRAS-002 ENSP00000309845
ENST00000311189
P01112
Show all »
Show » Show » 189 21.3 No 0
HRAS-004 ENSP00000380722
ENST00000397594
P01112
Show all »
Show » Show » 170 18.9 No 0
HRAS-009 ENSP00000380723
ENST00000397596
P01112
Show all »
Show » Show » 189 21.3 No 0
HRAS-201 ENSP00000388246
ENST00000417302
P01112
Show all »
Show » Show » 170 18.9 No 0
HRAS-202 ENSP00000407586
ENST00000451590
P01112
Show all »
Show » Show » 189 21.3 No 0