ATR

GENE INFORMATION

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Gene name

ATR (HGNC Symbol)

Synonyms

FRP1, MEC1, SCKL, SCKL1

Description

ataxia telangiectasia and Rad3 related (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

q23

Chromosome location (bp)

142168077 - 142297668

Ensembl

ENSG00000175054 (version 73.37)

Entrez gene

545

UniProt

Q13535 (UniProt - Evidence at protein level)

neXtProt

NX_Q13535

Antibodypedia

ATR antibodies
 

PROTEIN VIEW

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ATR-001
 
ATR-002
 
ATR-003
 
ATR-005
 
ATR-008
 
ATR-013
 
ATR-014
 
ATR-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATR-001 ENSP00000343741
ENST00000350721
Q13535
Show all »
Show » Show » 2644 301.4 No 1
ATR-002 ENSP00000424355
ENST00000513291
Show » Show » 457 52.2 No 0
ATR-003 ENSP00000426595
ENST00000507148
D6RFJ6
Show all »
100 11 No 0
ATR-005 ENSP00000425897
ENST00000515149
D6RIG7
Show all »
Show » 309 35.4 No 0
ATR-008 ENSP00000424754
ENST00000514393
H0Y9Q8
Show all »
50 6.1 No 0
ATR-013 ENSP00000422553
ENST00000504521
H0Y8Y6
Show all »
Show » 80 9 No 0
ATR-014 ENSP00000421870
ENST00000515810
H0Y8R8
Show all »
39 4.5 No 0
ATR-201 ENSP00000372581
ENST00000383101
Q13535
Show all »
Show » Show » 2580 294.2 No 1