PARL

GENE INFORMATION

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Gene name

PARL (HGNC Symbol)

Synonyms

PRO2207, PSARL, PSARL1, RHBDS1

Description

presenilin associated, rhomboid-like (HGNC Symbol)

Entrez gene summary

This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

q27.1

Chromosome location (bp)

183547173 - 183602721

Ensembl

ENSG00000175193 (version 73.37)

Entrez gene

55486

UniProt

Q9H300 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H300

Antibodypedia

PARL antibodies
 

PROTEIN VIEW

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PARL-001
 
PARL-002
 
PARL-004
 
PARL-005
 
PARL-007
 
PARL-008
 
PARL-009
 
PARL-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PARL-001 ENSP00000325421
ENST00000317096
Q9H300
Show all »
Show » Show » 379 42.2 No 7
PARL-002 ENSP00000310676
ENST00000311101
Q9H300
Show all »
Show » Show » 329 36.6 No 5
PARL-004 ENSP00000404421
ENST00000421484
F8WCQ4
Show all »
Show » Show » 173 19.6 No 0
PARL-005 ENSP00000396691
ENST00000449306
Show » Show » 159 17.6 No 0
PARL-007 ENSP00000402137
ENST00000435888
C9JNP8
Show all »
Show » Show » 295 33.1 No 3
PARL-008 ENSP00000402689
ENST00000450375
H7C1V6
Show all »
Show » 63 6.8 No 0
PARL-009 ENSP00000398043
ENST00000417784
Show » Show » 171 18.6 No 3
PARL-010 ENSP00000392926
ENST00000418450
Show » 112 12.1 No 1